SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner.
The Forkhead transcription factor FOXA2 plays a fundamental role in controlling edgewater shoes metabolic homeostasis in the liver during fasting.The precise molecular regulation of FOXA2 in response to nutrients is not fully understood.Here, we studied whether FOXA2 could be controlled at a post-translational level by acetylation.By means of LC-MS